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Perform by Many others, which includes Dickey, has demonstrated that upsized mucin secretion within the airways works in Considerably the same way, involving analogous vesicles (full of mucin rather than neurotransmitters) and synaptotagmin and collaborating proteins.
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In these mutant mice, secretory cells’ expulsion of mucin was decreased by about 70%, and mucus-plaque formation inside the airway was diminished by Virtually seventy five%, when compared with wild-type mice. Synaptotagmin was clearly a authentic therapeutic target.
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